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Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2
Cleavage of the amyloid precursor protein (APP) is a crucial event in Alzheimer disease pathogenesis that creates the amyloid-β peptide (Aβ) and liberates the carboxy-terminal APP intracellular domain (AICD) into the cytosol. The interaction of the APP C terminus with the adaptor protein Fe65 mediat...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2581855/ https://ncbi.nlm.nih.gov/pubmed/18833287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.188 |
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