Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction

Physiological function and pathology of the Alzheimer’s disease causing amyloid precursor protein (APP) are correlated with its cytosolic adaptor Fe65 encompassing a WW and two phosphotyrosine-binding domains (PTBs). The C-terminal Fe65-PTB2 binds a large portion of the APP intracellular domain (AIC...

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Pubblicato in:Front Mol Neurosci
Autori principali: Feilen, Lukas P., Haubrich, Kevin, Strecker, Paul, Probst, Sabine, Eggert, Simone, Stier, Gunter, Sinning, Irmgard, Konietzko, Uwe, Kins, Stefan, Simon, Bernd, Wild, Klemens
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425604/
https://ncbi.nlm.nih.gov/pubmed/28553201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00140
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