Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2

Cleavage of the amyloid precursor protein (APP) is a crucial event in Alzheimer disease pathogenesis that creates the amyloid-β peptide (Aβ) and liberates the carboxy-terminal APP intracellular domain (AICD) into the cytosol. The interaction of the APP C terminus with the adaptor protein Fe65 mediat...

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Hlavní autoři: Radzimanowski, Jens, Simon, Bernd, Sattler, Michael, Beyreuther, Konrad, Sinning, Irmgard, Wild, Klemens
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
Témata:
Scientific Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581855/
https://ncbi.nlm.nih.gov/pubmed/18833287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.188
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