RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis

Por Chan, Ho Yin Edwin
Publicado no Front Cell Neurosci (2014)

Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases

Por Koon, Alex C., Chan, Ho Yin Edwin
Publicado no Front Cell Neurosci (2017)

Expanded polyalanine tracts function as nuclear export signals and promote protein mislocalization via eEF1A1 factor

Por Li, Li, Ng, Nelson Ka Lam, Koon, Alex Chun, Chan, Ho Yin Edwin
Publicado no J Biol Chem (2017)

CAG expansion induces nucleolar stress in polyglutamine diseases

Por Tsoi, Ho, Lau, Terrence Chi-Kong, Tsang, Suk-Ying, Lau, Kwok-Fai, Chan, Ho Yin Edwin
Publicado em 2012

Whole-genome sequencing of two probands with hereditary spastic paraplegia reveals novel splice-donor region variant and known pathogenic variant in SPG11

Por Yu, Allen Chi-Shing, Chan, Anne Yin-Yan, Au, Wing Chi, Shen, Yun, Chan, Ting Fung, Chan, Ho-Yin Edwin
Publicado no Cold Spring Harb Mol Case Stud (2016)

FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth

Por Cheung, Hei Nga Maggie, Dunbar, Charlotte, Mórotz, Gábor M., Cheng, Wai Hang, Chan, Ho Yin Edwin, Miller, Christopher C. J., Lau, Kwok-Fai
Publicado no FASEB J (2013)

Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

Por Zhang, Qian, Tsoi, Ho, Peng, Shaohong, Li, Pan P., Lau, Kwok-Fai, Rudnicki, Dobrila D., Ngo, Jacky Chi-Ki, Chan, Ho Yin Edwin
Publicado no Dis Model Mech (2016)

The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity

Por Ng, Chun-Fai, Ko, Chun-Hay, Koon, Chi-Man, Xian, Jia-Wen, Leung, Ping-Chung, Fung, Kwok-Pui, Chan, Ho Yin Edwin, Lau, Clara Bik-San
Publicado em 2013

Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65

Por Sun, Xin, Li, Pan P., Zhu, Shanshan, Cohen, Rachael, Marque, Leonard O., Ross, Christopher A., Pulst, Stefan M., Chan, Ho Yin Edwin, Margolis, Russell L., Rudnicki, Dobrila D.
Publicado no Sci Rep (2015)

Phosphorylation of FE65 Ser(610) by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing

Por Chow, Wan Ning Vanessa, Ngo, Jacky Chi Ki, Li, Wen, Chen, Yu Wai, Tam, Ka Ming Vincent, Chan, Ho Yin Edwin, Miller, Christopher C.J., Lau, Kwok-Fai
Publicado no Biochem J (2015)

A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases

Por Zhang, Qian, Yang, Mengbi, Sørensen, Kasper K., Madsen, Charlotte S., Boesen, Josephine T., An, Ying, Peng, Shao Hong, Wei, Yuming, Wang, Qianwen, Jensen, Knud J., Zuo, Zhong, Chan, Ho Yin Edwin, Ngo, Jacky Chi Ki
Publicado no Sci Rep (2017)