Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65

Huntington’s disease (HD) is caused by a CAG repeat expansion in the huntingtin (HTT) gene. Recent evidence suggests that HD is a consequence of multimodal, non-mutually exclusive mechanisms of pathogenesis that involve both HTT protein- and HTT RNA-triggered mechanisms. Here we provide further evid...

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Publicado no:Sci Rep
Main Authors: Sun, Xin, Li, Pan P., Zhu, Shanshan, Cohen, Rachael, Marque, Leonard O., Ross, Christopher A., Pulst, Stefan M., Chan, Ho Yin Edwin, Margolis, Russell L., Rudnicki, Dobrila D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517393/
https://ncbi.nlm.nih.gov/pubmed/26218986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12521
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