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Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65
Huntington’s disease (HD) is caused by a CAG repeat expansion in the huntingtin (HTT) gene. Recent evidence suggests that HD is a consequence of multimodal, non-mutually exclusive mechanisms of pathogenesis that involve both HTT protein- and HTT RNA-triggered mechanisms. Here we provide further evid...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4517393/ https://ncbi.nlm.nih.gov/pubmed/26218986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12521 |
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