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The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing
Myotonic dystrophy type 1 (DM1) is a genetic disorder linked to a (CTG)(n) repeat expansion in the 3′ untranslated region of the DMPK gene. Upon transcription in the nucleus, the CUG repeats form a stable RNA stem-loop that sequesters the RNA-binding protein MBNL1 from its normal function in the cel...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2695092/ https://ncbi.nlm.nih.gov/pubmed/19470458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900342106 |
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