Splicing inhibition of U2AF(65) leads to alternative exon skipping

U2 snRNP auxiliary factor 65 kDa (U2AF(65)) is a general splicing factor that contacts polypyrimidine (Py) tract and promotes prespliceosome assembly. In this report, we show that U2AF(65) stimulates alternative exon skipping in spinal muscular atrophy (SMA)-related survival motor neuron (SMN) pre-m...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cho, Sunghee, Moon, Heegyum, Loh, Tiing Jen, Jang, Ha Na, Liu, Yongchao, Zhou, Jianhua, Ohn, Takbum, Zheng, Xuexiu, Shen, Haihong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538632/
https://ncbi.nlm.nih.gov/pubmed/26216990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500639112
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