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Activation of Cryptic 3′ Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping
Here we show that the serine/arginine rich splicing factor 2 (SRSF2) promotes cryptic 3′ splice-site (3′AG′) usage during cassette exon exclusion in survival of motor neuron (SMN2) minigenes. Deletion of the 3′AG′ (3′AG′1), its associated branch point (BP′) and polypyrimidine tract (PPT′) sequences...
Tallennettuna:
| Julkaisussa: | Cells |
|---|---|
| Päätekijät: | , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
MDPI
2019
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6678912/ https://ncbi.nlm.nih.gov/pubmed/31295920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8070696 |
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