SRSF2 directly inhibits intron splicing to suppresses cassette exon inclusion

SRSF2, a Serine-Arginine rich (SR) protein, is a splicing activator that mediates exon inclusion and exclusion events equally well. Here we show SRSF2 directly suppresses intron splicing to suppress cassette exon inclusion in SMN pre-mRNA. Through a serial mutagenesis, we demonstrate that a 10 nt RN...

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Udgivet i:BMB Rep
Main Authors: Moon, Heegyum, Cho, Sunghee, Loh, Tiing Jen, Jang, Ha Na, Liu, Yongchao, Choi, Namjeong, Oh, Jagyeong, Ha, Jiyeon, Zhou, Jianhua, Cho, Sungchan, Kim, Dong-Eun, Ye, Michael B., Zheng, Xuexiu, Shen, Haihong
Format: Artigo
Sprog:Inglês
Udgivet: Korean Society for Biochemistry and Molecular Biology 2017
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595172/
https://ncbi.nlm.nih.gov/pubmed/28712387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2017.50.8.103
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