Relative strength of 5’ splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA

Bcl-x, a member of the Bcl-2 family, plays a key role in apoptosis. Alternative splicing of Bcl-x pre-mRNA through alternative 5’ splice-site selection produces an anti-apoptotic mRNA isoform that includes exon 2b and a pro-apoptotic Bcl-x mRNA isoform that excludes exon 2b. Here we used Bcl-x minig...

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Vydáno v:BMB Rep
Hlavní autoři: Choi, Namjeong, Liu, Yongchao, Oh, Jagyeong, Ha, Jiyeon, Ghigna, Claudia, Zheng, Xuexiu, Shen, Haihong
Médium: Artigo
Jazyk:Inglês
Vydáno: Korean Society for Biochemistry and Molecular Biology 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8016662/
https://ncbi.nlm.nih.gov/pubmed/33050987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2021.54.3.170
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