hnRNP A1 Regulates Alternative Splicing of Tau Exon 10 by Targeting 3′ Splice Sites

The ratio control of 4R-Tau/3R-Tau by alternative splicing of Tau exon 10 is important for maintaining brain functions. In this study, we show that hnRNP A1 knockdown induces inclusion of endogenous Tau exon 10, conversely, overexpression of hnRNP A1 promotes exon 10 skipping of Tau. In addition, hn...

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Bibliographic Details
Published in:Cells
Main Authors: Liu, Yongchao, Kim, Donggun, Choi, Namjeong, Oh, Jagyeong, Ha, Jiyeon, Zhou, Jianhua, Zheng, Xuexiu, Shen, Haihong
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226981/
https://ncbi.nlm.nih.gov/pubmed/32290247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9040936
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