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Targeting of U2AF(65) to Sites of Active Splicing in the Nucleus

U2AF(65) is an essential splicing factor that promotes binding of U2 small nuclear (sn)RNP at the pre-mRNA branchpoint. Here we describe a novel monoclonal antibody that reacts specifically with U2AF(65). Using this antibody, we show that U2AF(65) is diffusely distributed in the nucleoplasm with add...

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Autori principali: Gama-Carvalho, Margarida, Krauss, Randy D., Chiang, Lijian, Valcárcel, Juan, Green, Michael R., Carmo-Fonseca, Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2136214/
https://ncbi.nlm.nih.gov/pubmed/9166400
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