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An extended U2AF(65)–RNA-binding domain recognizes the 3′ splice site signal
How the essential pre-mRNA splicing factor U2AF(65) recognizes the polypyrimidine (Py) signals of the major class of 3′ splice sites in human gene transcripts remains incompletely understood. We determined four structures of an extended U2AF(65)–RNA-binding domain bound to Py-tract oligonucleotides...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4786784/ https://ncbi.nlm.nih.gov/pubmed/26952537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10950 |
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