An extended U2AF(65)–RNA-binding domain recognizes the 3′ splice site signal

How the essential pre-mRNA splicing factor U2AF(65) recognizes the polypyrimidine (Py) signals of the major class of 3′ splice sites in human gene transcripts remains incompletely understood. We determined four structures of an extended U2AF(65)–RNA-binding domain bound to Py-tract oligonucleotides...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Nat Commun
Autores principales: Agrawal, Anant A., Salsi, Enea, Chatrikhi, Rakesh, Henderson, Steven, Jenkins, Jermaine L., Green, Michael R., Ermolenko, Dmitri N., Kielkopf, Clara L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786784/
https://ncbi.nlm.nih.gov/pubmed/26952537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10950
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares