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A Broad Range of Conformations Contribute to the Solution Ensemble of the Essential Splicing Factor U2AF(65)
U2AF(65) is essential for pre-mRNA splicing in most eukaryotes. Two consecutive RNA recognition motifs (RRM) of U2AF(65) recognize a polypyrimidine tract at the 3′ splice site. Here, we use small-angle X-ray scattering to demonstrate that the tandem U2AF(65) RRMs exhibit a broad range of conformatio...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3447987/ https://ncbi.nlm.nih.gov/pubmed/22702716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300277t |
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