A splice site-sensing conformational switch in U2AF2 is modulated by U2AF1 and its recurrent myelodysplasia-associated mutation

An essential heterodimer of the U2AF1 and U2AF2 pre-mRNA splicing factors nucleates spliceosome assembly at polypyrimidine (Py) signals preceding the major class of 3′ splice sites. U2AF1 frequently acquires an S34F-encoding mutation among patients with myelodysplastic syndromes (MDS). The influence...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Warnasooriya, Chandani, Feeney, Callen F, Laird, Kholiswa M, Ermolenko, Dmitri N, Kielkopf, Clara L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
RNA and RNA-protein complexes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261175/
https://ncbi.nlm.nih.gov/pubmed/32343311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa293
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge