Crystal Structures of Matriptase in Complex with Its Inhibitor Hepatocyte Growth Factor Activator Inhibitor-1

Por Zhao, Baoyu, Yuan, Cai, Li, Rui, Qu, Dan, Huang, Mingdong, Ngo, Jacky Chi Ki
Publicado em 2013

Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

Por Zhang, Qian, Tsoi, Ho, Peng, Shaohong, Li, Pan P., Lau, Kwok-Fai, Rudnicki, Dobrila D., Ngo, Jacky Chi-Ki, Chan, Ho Yin Edwin
Publicado no Dis Model Mech (2016)

Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1

Por Li, Wen, Tam, Ka Ming Vincent, Chan, Wai Wa Ray, Koon, Alex Chun, Ngo, Jacky Chi Ki, Chan, Ho Yin Edwin, Lau, Kwok-Fai
Publicado no J Biol Chem (2018)

A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior

Por Kromann-Hansen, Tobias, Oldenburg, Emil, Yung, Kristen Wing Yu, Ghassabeh, Gholamreza H., Muyldermans, Serge, Declerck, Paul J., Huang, Mingdong, Andreasen, Peter A., Ngo, Jacky Chi Ki
Publicado no J Biol Chem (2016)

A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

Por Zhang, Qian, Chen, Zhefan Stephen, An, Ying, Liu, Haizhen, Hou, Yonghui, Li, Wen, Lau, Kwok-Fai, Koon, Alex Chun, Ngo, Jacky Chi Ki, Chan, Ho Yin Edwin
Publicado no RNA (2018)

A Sliding Docking Interaction Is Essential for Sequential and Processive Phosphorylation of an SR Protein by SRPK1

Por Ngo, Jacky Chi Ki, Giang, Kayla, Chakrabarti, Sutapa, Ma, Chen-Ting, Huynh, Nhat, Hagopian, Jonathan C., Dorrestein, Pieter C., Fu, Xiang-Dong, Adams, Joseph A., Ghosh, Gourisankar
Publicado em 2008

Phosphorylation of FE65 Ser(610) by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing

Por Chow, Wan Ning Vanessa, Ngo, Jacky Chi Ki, Li, Wen, Chen, Yu Wai, Tam, Ka Ming Vincent, Chan, Ho Yin Edwin, Miller, Christopher C.J., Lau, Kwok-Fai
Publicado no Biochem J (2015)

Identification of influenza polymerase inhibitors targeting C-terminal domain of PA through surface plasmon resonance screening

Por Lo, Chun-Yeung, Li, Olive Tin-Wai, Tang, Wen-Ping, Hu, Chun, Wang, Guo Xin, Ngo, Jacky Chi-Ki, Wan, David Chi-Cheong, Poon, Leo Lit-Man, Shaw, Pang-Chui
Publicado no Sci Rep (2018)

A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases

Por Zhang, Qian, Yang, Mengbi, Sørensen, Kasper K., Madsen, Charlotte S., Boesen, Josephine T., An, Ying, Peng, Shao Hong, Wei, Yuming, Wang, Qianwen, Jensen, Knud J., Zuo, Zhong, Chan, Ho Yin Edwin, Ngo, Jacky Chi Ki
Publicado no Sci Rep (2017)

SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform

Por Hatcher, John M., Wu, Guowei, Zeng, Chuyue, Zhu, Jie, Meng, Fan, Patel, Sherrina, Wang, Wenqiu, Ficarro, Scott B., Leggett, Alan L., Powell, Chelsea E., Marto, Jarrod A., Zhang, Kang, Ngo, Jacky Chi Ki, Fu, Xiang-Dong, Zhang, Tinghu, Gray, Nathanael S.
Publicado no Cell Chem Biol (2018)