Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

Polyglutamine (polyQ) diseases represent a group of progressive neurodegenerative disorders that are caused by abnormal expansion of CAG triplet nucleotides in disease genes. Recent evidence indicates that not only mutant polyQ proteins, but also their corresponding mutant RNAs, contribute to the pa...

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Detalles Bibliográficos
Publicado en:Dis Model Mech
Main Authors: Zhang, Qian, Tsoi, Ho, Peng, Shaohong, Li, Pan P., Lau, Kwok-Fai, Rudnicki, Dobrila D., Ngo, Jacky Chi-Ki, Chan, Ho Yin Edwin
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Ltd 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833327/
https://ncbi.nlm.nih.gov/pubmed/26839389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.022350
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