Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

Polyglutamine (polyQ) diseases represent a group of progressive neurodegenerative disorders that are caused by abnormal expansion of CAG triplet nucleotides in disease genes. Recent evidence indicates that not only mutant polyQ proteins, but also their corresponding mutant RNAs, contribute to the pa...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Dis Model Mech
Egile Nagusiak: Zhang, Qian, Tsoi, Ho, Peng, Shaohong, Li, Pan P., Lau, Kwok-Fai, Rudnicki, Dobrila D., Ngo, Jacky Chi-Ki, Chan, Ho Yin Edwin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Company of Biologists Ltd 2016
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833327/
https://ncbi.nlm.nih.gov/pubmed/26839389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.022350
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