A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior

A peptide segment that binds the active site of a serine protease in a substrate-like manner may behave like an inhibitor or a substrate. However, there is sparse information on which factors determine the behavior a particular peptide segment will exhibit. Here, we describe the first x-ray crystal...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kromann-Hansen, Tobias, Oldenburg, Emil, Yung, Kristen Wing Yu, Ghassabeh, Gholamreza H., Muyldermans, Serge, Declerck, Paul J., Huang, Mingdong, Andreasen, Peter A., Ngo, Jacky Chi Ki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946931/
https://ncbi.nlm.nih.gov/pubmed/27226628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.732503
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