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Expanded polyalanine tracts function as nuclear export signals and promote protein mislocalization via eEF1A1 factor

Polyalanine (poly(A)) diseases are caused by the expansion of translated GCN triplet nucleotide sequences encoding poly(A) tracts in proteins. To date, nine human disorders have been found to be associated with poly(A) tract expansions, including congenital central hypoventilation syndrome and oculo...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Li, Li, Ng, Nelson Ka Lam, Koon, Alex Chun, Chan, Ho Yin Edwin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392573/
https://ncbi.nlm.nih.gov/pubmed/28246169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.763599
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