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Expanded polyalanine tracts function as nuclear export signals and promote protein mislocalization via eEF1A1 factor
Polyalanine (poly(A)) diseases are caused by the expansion of translated GCN triplet nucleotide sequences encoding poly(A) tracts in proteins. To date, nine human disorders have been found to be associated with poly(A) tract expansions, including congenital central hypoventilation syndrome and oculo...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5392573/ https://ncbi.nlm.nih.gov/pubmed/28246169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.763599 |
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