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Allosteric Interactions Direct Binding and Phosphorylation of ASF/SF2 by SRPK1
ASF/SF2, a member of the serine-arginine (SR) protein family, has two RRM domains (RRM1 and RRM2) and a C-terminus domain rich in RS dipeptides. The SR protein kinase 1 (SRPK1) phosphorylates approximately 12 of these serines using a semi-processive mechanism. The x-ray structure of the ASF/SF2:SRPK...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3322178/ https://ncbi.nlm.nih.gov/pubmed/19886675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901107q |
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