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Allosteric Interactions Direct Binding and Phosphorylation of ASF/SF2 by SRPK1

ASF/SF2, a member of the serine-arginine (SR) protein family, has two RRM domains (RRM1 and RRM2) and a C-terminus domain rich in RS dipeptides. The SR protein kinase 1 (SRPK1) phosphorylates approximately 12 of these serines using a semi-processive mechanism. The x-ray structure of the ASF/SF2:SRPK...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Huynh, Nhat, Ma, Chen-Ting, Giang, Ngoc, Hagopian, Jonathan, Ngo, Jacky, Adams, Joseph, Ghosh, Gourisankar
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322178/
https://ncbi.nlm.nih.gov/pubmed/19886675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901107q
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