Identification of Candidate Small-Molecule Therapeutics to Cancer by Gene-Signature Perturbation in Connectivity Mapping

Por McArt, Darragh G., Zhang, Shu-Dong
Publicado em 2011

cudaMap: a GPU accelerated program for gene expression connectivity mapping

Por McArt, Darragh G, Bankhead, Peter, Dunne, Philip D, Salto-Tellez, Manuel, Hamilton, Peter, Zhang, Shu-Dong
Publicado em 2013

Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer

Por Hutchinson, Ryan A, Adams, Richard A, McArt, Darragh G, Salto-Tellez, Manuel, Jasani, Bharat, Hamilton, Peter W
Publicado no J Transl Med (2015)

Connectivity Mapping for Candidate Therapeutics Identification Using Next Generation Sequencing RNA-Seq Data

Por McArt, Darragh G., Dunne, Philip D., Blayney, Jaine K., Salto-Tellez, Manuel, Van Schaeybroeck, Sandra, Hamilton, Peter W., Zhang, Shu-Dong
Publicado em 2013

KRAS mutant colorectal cancer gene signatures identified angiotensin II receptor blockers as potential therapies

Por Wen, Qing, Dunne, Philip D., O’Reilly, Paul G., Li, Gerald, Bjourson, Anthony J., McArt, Darragh G., Hamilton, Peter W., Zhang, Shu-Dong
Publicado no Oncotarget (2016)

Quantification of HER2 heterogeneity in breast cancer–implications for identification of sub-dominant clones for personalised treatment

Por Buckley, Niamh E., Forde, Claire, McArt, Darragh G., Boyle, David P., Mullan, Paul B., James, Jacqueline A., Maxwell, Perry, McQuaid, Stephen, Salto-Tellez, Manuel
Publicado no Sci Rep (2016)

Validation of Next Generation Sequencing Technologies in Comparison to Current Diagnostic Gold Standards for BRAF, EGFR and KRAS Mutational Analysis

Por McCourt, Clare M., McArt, Darragh G., Mills, Ken, Catherwood, Mark A., Maxwell, Perry, Waugh, David J., Hamilton, Peter, O'Sullivan, Joe M., Salto-Tellez, Manuel
Publicado em 2013

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

Por O’Reilly, Paul G., Wen, Qing, Bankhead, Peter, Dunne, Philip D., McArt, Darragh G., McPherson, Suzanne, Hamilton, Peter W., Mills, Ken I., Zhang, Shu-Dong
Publicado no BMC Bioinformatics (2016)

Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer

Por Dunne, Philip D., O'Reilly, Paul G., Coleman, Helen G., Gray, Ronan T., Longley, Daniel B., Johnston, Patrick G., Salto-Tellez, Manuel, Lawler, Mark, McArt, Darragh G.
Publicado no Oncotarget (2016)

Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer

Por Bradley, Conor A., Dunne, Philip D., Bingham, Victoria, McQuaid, Stephen, Khawaja, Hajrah, Craig, Stephanie, James, Jackie, Moore, Wendy L., McArt, Darragh G., Lawler, Mark, Dasgupta, Sonali, Johnston, Patrick G., Van Schaeybroeck, Sandra
Publicado no Oncotarget (2016)

AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early stage colon cancer

Por Dunne, Philip D., McArt, Darragh G., Blayney, Jaine K., Kalimutho, Murugan, Greer, Samanda, Wang, Tingting, Srivastava, Supriya, Ong, Chee Wee, Arthur, Ken, Loughrey, Maurice, Redmond, Keara, Longley, Daniel B., Salto-Tellez, Manuel, Johnston, Patrick G., Van Schaeybroeck, Sandra
Publicado em 2013

Automated tumor analysis for molecular profiling in lung cancer

Por Hamilton, Peter W., Wang, Yinhai, Boyd, Clinton, James, Jacqueline A., Loughrey, Maurice B., Hougton, Joseph P., Boyle, David P., Kelly, Paul, Maxwell, Perry, McCleary, David, Diamond, James, McArt, Darragh G., Tunstall, Jonathon, Bankhead, Peter, Salto-Tellez, Manuel
Publicado no Oncotarget (2015)

The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers

Por Ong, Chee Wee, Chong, Pei Yi, McArt, Darragh G., Chan, Jason Yongsheng, Tan, Hwee Tong, Kumar, Alan Prem, Chung, Maxey C. M., Clément, Marie-Véronique, Soong, Richie, Van Schaeybroeck, Sandra, Waugh, David J. J., Johnston, Patrick G., Dunne, Philip D., Salto-Tellez, Manuel
Publicado no Oncotarget (2015)

EphA2 expression is a key driver of migration and invasion and a poor prognostic marker in colorectal cancer

Por Dunne, Philip D., Dasgupta, Sonali, Blayney, Jaine K., McArt, Darragh G., Redmond, Keara L., Weir, Jessica-Anne, Bradley, Conor A., Sasazuki, Takehiko, Shirasawa, Senji, Wang, Tingting, Srivastava, Supriya, Ong, Chee Wee, Arthur, Ken, Salto-Tellez, Manuel, Wilson, Richard H., Johnston, Patrick G., Van Schaeybroeck, Sandra
Publicado no Clin Cancer Res (2015)

Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility

Por Alvi, Muhammad A., McArt, Darragh G., Kelly, Paul, Fuchs, Marc-Aurel, Alderdice, Matthew, McCabe, Clare M., Bingham, Victoria, McGready, Claire, Tripathi, Shailesh, Emmert-Streib, Frank, Loughrey, Maurice B., McQuaid, Stephen, Maxwell, Perry, Hamilton, Peter W., Turkington, Richard, James, Jacqueline A., Wilson, Richard H., Salto-Tellez, Manuel
Publicado no Oncotarget (2015)

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.

Por D'Costa, Zenobia C., Higgins, Catherine, Ong, Chee Wee, Irwin, Gareth W., Boyle, David, McArt, Darragh G., McCloskey, Karen, Buckley, Niamh E., Crawford, Nyree T., Thiagarajan, Lalitha, Murray, James T., Kennedy, Richard D., Mulligan, Karl A., Harkin, D. Paul, Waugh, David J.J., Scott, Chris J., Salto-Tellez, Manuel, Williams, Richard, Mullan, Paul B.
Publicado em 2014

Delivering a research‐enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program

Por Lawler, Mark, Gavin, Anna, Salto‐Tellez, Manuel, Kennedy, Richard D., Van Schaeybroeck, Sandra, Wilson, Richard H., Harkin, Denis Paul, Grayson, Margaret, Boyd, Ruth E., Hamilton, Peter W., McArt, Darragh G., James, Jacqueline, Robson, Tracy, Ladner, Robert D., Prise, Kevin M., O'Sullivan, Joe M., Harrison, Timothy, Murray, Liam, Johnston, Patrick G., Waugh, David J.
Publicado no Cancer (2015)