Identification of Candidate Small-Molecule Therapeutics to Cancer by Gene-Signature Perturbation in Connectivity Mapping

por McArt, Darragh G., Zhang, Shu-Dong
Publicado 2011

cudaMap: a GPU accelerated program for gene expression connectivity mapping

por McArt, Darragh G, Bankhead, Peter, Dunne, Philip D, Salto-Tellez, Manuel, Hamilton, Peter, Zhang, Shu-Dong
Publicado 2013

Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer

por Hutchinson, Ryan A, Adams, Richard A, McArt, Darragh G, Salto-Tellez, Manuel, Jasani, Bharat, Hamilton, Peter W
Publicado en J Transl Med (2015)

Connectivity Mapping for Candidate Therapeutics Identification Using Next Generation Sequencing RNA-Seq Data

por McArt, Darragh G., Dunne, Philip D., Blayney, Jaine K., Salto-Tellez, Manuel, Van Schaeybroeck, Sandra, Hamilton, Peter W., Zhang, Shu-Dong
Publicado 2013

KRAS mutant colorectal cancer gene signatures identified angiotensin II receptor blockers as potential therapies

por Wen, Qing, Dunne, Philip D., O’Reilly, Paul G., Li, Gerald, Bjourson, Anthony J., McArt, Darragh G., Hamilton, Peter W., Zhang, Shu-Dong
Publicado en Oncotarget (2016)

Embracing an integromic approach to tissue biomarker research in cancer: Perspectives and lessons learned

por Li, Gerald, Bankhead, Peter, Dunne, Philip D, O’Reilly, Paul G, James, Jacqueline A, Salto-Tellez, Manuel, Hamilton, Peter W, McArt, Darragh G
Publicado en Brief Bioinform (2017)

Quantification of HER2 heterogeneity in breast cancer–implications for identification of sub-dominant clones for personalised treatment

por Buckley, Niamh E., Forde, Claire, McArt, Darragh G., Boyle, David P., Mullan, Paul B., James, Jacqueline A., Maxwell, Perry, McQuaid, Stephen, Salto-Tellez, Manuel
Publicado en Sci Rep (2016)

Validation of Next Generation Sequencing Technologies in Comparison to Current Diagnostic Gold Standards for BRAF, EGFR and KRAS Mutational Analysis

por McCourt, Clare M., McArt, Darragh G., Mills, Ken, Catherwood, Mark A., Maxwell, Perry, Waugh, David J., Hamilton, Peter, O'Sullivan, Joe M., Salto-Tellez, Manuel
Publicado 2013

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

por O’Reilly, Paul G., Wen, Qing, Bankhead, Peter, Dunne, Philip D., McArt, Darragh G., McPherson, Suzanne, Hamilton, Peter W., Mills, Ken I., Zhang, Shu-Dong
Publicado en BMC Bioinformatics (2016)

Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer

por Dunne, Philip D., O'Reilly, Paul G., Coleman, Helen G., Gray, Ronan T., Longley, Daniel B., Johnston, Patrick G., Salto-Tellez, Manuel, Lawler, Mark, McArt, Darragh G.
Publicado en Oncotarget (2016)

Prostate cancer heterogeneity assessment with multi-regional sampling and alignment-free methods

por Murphy, Ross G, Roddy, Aideen C, Srivastava, Shambhavi, Baena, Esther, Waugh, David J, M. O’Sullivan, Joe, McArt, Darragh G, Jain, Suneil, LaBonte, Melissa J
Publicado en NAR Genom Bioinform (2020)

Depletion of DNMT1 in differentiated human cells highlights key classes of sensitive genes and an interplay with polycomb repression

por O’Neill, Karla M., Irwin, Rachelle E., Mackin, Sarah-Jayne, Thursby, Sara-Jayne, Thakur, Avinash, Bertens, Ciske, Masala, Laura, Loughery, Jayne E. P., McArt, Darragh G., Walsh, Colum P.
Publicado en Epigenetics Chromatin (2018)

NUQA: Estimating Cancer Spatial and Temporal Heterogeneity and Evolution through Alignment-Free Methods

por Roddy, Aideen C, Jurek-Loughrey, Anna, Souza, Jose, Gilmore, Alan, O’Reilly, Paul G, Stupnikov, Alexey, Gonzalez de Castro, David, Prise, Kevin M, Salto-Tellez, Manuel, McArt, Darragh G
Publicado en Mol Biol Evol (2019)

Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer

por Bibby, Becky A. S., Thiruthaneeswaran, Niluja, Yang, Lingjian, Pereira, Ronnie R., More, Elisabet, McArt, Darragh G., O’Reilly, Paul, Bristow, Robert G., Williams, Kaye J., Choudhury, Ananya, West, Catharine M. L.
Publicado en BMC Urol (2021)

Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer

por Bradley, Conor A., Dunne, Philip D., Bingham, Victoria, McQuaid, Stephen, Khawaja, Hajrah, Craig, Stephanie, James, Jackie, Moore, Wendy L., McArt, Darragh G., Lawler, Mark, Dasgupta, Sonali, Johnston, Patrick G., Van Schaeybroeck, Sandra
Publicado en Oncotarget (2016)

IHC-based subcellular quantification provides new insights into prognostic relevance of FLIP and procaspase-8 in non-small-cell lung cancer

por Hutchinson, Ryan A, Coleman, Helen G, Gately, Kathy, Young, Vincent, Nicholson, Siobhan, Cummins, Robert, Kay, Elaine, Hynes, Sean O, Dunne, Philip D, Senevirathne, Seedevi, Hamilton, Peter W, McArt, Darragh G, Longley, Daniel B
Publicado en Cell Death Discov (2017)

QuPath: Open source software for digital pathology image analysis

por Bankhead, Peter, Loughrey, Maurice B., Fernández, José A., Dombrowski, Yvonne, McArt, Darragh G., Dunne, Philip D., McQuaid, Stephen, Gray, Ronan T., Murray, Liam J., Coleman, Helen G., James, Jacqueline A., Salto-Tellez, Manuel, Hamilton, Peter W.
Publicado en Sci Rep (2017)

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification

por Dunne, Philip D., Alderdice, Matthew, O'Reilly, Paul G., Roddy, Aideen C., McCorry, Amy M. B., Richman, Susan, Maughan, Tim, McDade, Simon S., Johnston, Patrick G., Longley, Daniel B., Kay, Elaine, McArt, Darragh G., Lawler, Mark
Publicado en Nat Commun (2017)

Prospective patient stratification into robust cancer‐cell intrinsic subtypes from colorectal cancer biopsies

por Alderdice, Matthew, Richman, Susan D, Gollins, Simon, Stewart, James P, Hurt, Chris, Adams, Richard, McCorry, Amy MB, Roddy, Aideen C, Vimalachandran, Dale, Isella, Claudio, Medico, Enzo, Maughan, Tim, McArt, Darragh G, Lawler, Mark, Dunne, Philip D
Publicado en J Pathol (2018)

AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early stage colon cancer

por Dunne, Philip D., McArt, Darragh G., Blayney, Jaine K., Kalimutho, Murugan, Greer, Samanda, Wang, Tingting, Srivastava, Supriya, Ong, Chee Wee, Arthur, Ken, Loughrey, Maurice, Redmond, Keara, Longley, Daniel B., Salto-Tellez, Manuel, Johnston, Patrick G., Van Schaeybroeck, Sandra
Publicado 2013