FLIP(L): the pseudo‐caspase

Por Smyth, Peter, Sessler, Tamas, Scott, Christopher J., Longley, Daniel B.
Publicado no FEBS J (2020)

Voltage dependent anion channel-1 regulates death receptor mediated apoptosis by enabling cleavage of caspase-8

Por Chacko, Alex D, Liberante, Fabio, Paul, Ian, Longley, Daniel B, Fennell, Dean A
Publicado em 2010

Epithelial‐to‐mesenchymal transition signature assessment in colorectal cancer quantifies tumour stromal content rather than true transition

Por McCorry, Amy MB, Loughrey, Maurice B, Longley, Daniel B, Lawler, Mark, Dunne, Philip D
Publicado no J Pathol (2018)

Chemotherapy-induced activation of ADAM-17: a novel mechanism of drug resistance in colorectal cancer

Por Kyula, Joan N., Van Schaeybroeck, Sandra, Doherty, Joanne, Fenning, Catherine S., Longley, Daniel B., Johnston, Patrick G.
Publicado em 2010

Constitutive and Treatment-Induced CXCL8-Signalling Selectively Modulates the Efficacy of Anti-Metabolite Therapeutics in Metastatic Prostate Cancer

Por Wilson, Catherine, Maxwell, Pamela J., Longley, Daniel B., Wilson, Richard H., Johnston, Patrick G., Waugh, David J. J.
Publicado em 2012

Src and ADAM-17-Mediated Shedding of Transforming Growth Factor-α Is a Mechanism of Acute Resistance to TRAIL

Por Van Schaeybroeck, Sandra, Kelly, Donal M., Kyula, Joan, Stokesberry, Susan, Fennell, Dean A., Johnston, Patrick G., Longley, Daniel B.
Publicado em 2008

Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform

Por Matveeva, Anna, Fichtner, Michael, McAllister, Katherine, McCann, Christopher, Sturrock, Marc, Longley, Daniel B., Prehn, Jochen H. M.
Publicado no PLoS Comput Biol (2019)

Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17

Por Van Schaeybroeck, Sandra, Kyula, Joan N., Fenton, Audrey, Fenning, Catherine S., Sasazuki, Takehiko, Shirasawa, Senji, Longley, Daniel B., Johnston, Patrick G.
Publicado em 2010

Calbindin 2 (CALB2) Regulates 5-Fluorouracil Sensitivity in Colorectal Cancer by Modulating the Intrinsic Apoptotic Pathway

Por Stevenson, Leanne, Allen, Wendy L., Proutski, Irina, Stewart, Gail, Johnston, Louise, McCloskey, Karen, Wilson, Peter M., Longley, Daniel B., Johnston, Patrick G.
Publicado em 2011

The Colorectal cancer disease-specific transcriptome may facilitate the discovery of more biologically and clinically relevant information

Por Allen, Wendy L, Jithesh, Puthen V, Oliver, Gavin R, Proutski, Irina, Longley, Daniel B, Lenz, Heinz-Josef, Proutski, Vitali, Harkin, Paul, Johnston, Patrick G
Publicado em 2010

HDAC inhibition overcomes acute resistance to MEK inhibition in BRAF mutant colorectal cancer by down-regulation of c-FLIP(L)

Por Carson, Robbie, Celtikci, Basak, Fenning, Cathy, Javadi, Arman, Crawford, Nyree, Carbonell, Lucia Perez, Lawler, Mark, Longley, Daniel B., Johnston, Patrick G., Van Schaeybroeck, Sandra
Publicado no Clin Cancer Res (2015)

Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711

Por Crawford, Nyree, Salvucci, Manuela, Hellwig, Christian T, Lincoln, Frank A, Mooney, Ruth E, O’Connor, Carla L, Prehn, Jochen HM, Longley, Daniel B, Rehm, Markus
Publicado no Cell Death Differ (2018)

ELEVATION OF C-FLIP IN CASTRATE-RESISTANT PROSTATE CANCER ANTAGONIZES THERAPEUTIC RESPONSE TO ANDROGEN-RECEPTOR TARGETED THERAPY

Por McCourt, Clare, Maxwell, Pamela, Mazzucchelli, Roberta, Montironi, Rodolfo, Scarpelli, Marina, Salto-Tellez, Manuel, O’Sullivan, Joe M., Longley, Daniel B., Waugh, David J.J.
Publicado em 2012

Vorinostat Eliminates Multicellular Resistance of Mesothelioma 3D Spheroids via Restoration of Noxa Expression

Por Barbone, Dario, Cheung, Priscilla, Battula, Sailaja, Busacca, Sara, Gray, Steven G., Longley, Daniel B., Bueno, Raphael, Sugarbaker, David J., Fennell, Dean A., Broaddus, V. Courtney
Publicado em 2012

Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer

Por Stevenson, Leanne, Allen, Wendy L, Turkington, Richard, Jithesh, Puthen V, Proutski, Irina, Stewart, Gail, Lenz, Heinz-Josef, Schaeybroeck, Sandra Van, Longley, Daniel B, Johnston, Patrick G
Publicado em 2012

Pharmacogenomic profiling and pathway analyses identify MAPK-dependent migration as an acute response to SN38 in p53 null and mutant colorectal cancer cells

Por Allen, Wendy L., Turkington, Richard C., Stevenson, Leanne, Carson, Gail, Coyle, Vicky M., Hector, Suzanne, Dunne, Philip, Van Schaeybroeck, Sandra, Longley, Daniel B., Johnston, Patrick G.
Publicado em 2012

Efficient Drug Delivery and Induction of Apoptosis in Colorectal Tumors Using a Death Receptor 5-Targeted Nanomedicine

Por Schmid, Daniela, Fay, Francois, Small, Donna M, Jaworski, Jakub, Riley, Joel S, Tegazzini, Diana, Fenning, Cathy, Jones, David S, Johnston, Patrick G, Longley, Daniel B, Scott, Christopher J
Publicado no Mol Ther (2014)

Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer

Por Dunne, Philip D., O'Reilly, Paul G., Coleman, Helen G., Gray, Ronan T., Longley, Daniel B., Johnston, Patrick G., Salto-Tellez, Manuel, Lawler, Mark, McArt, Darragh G.
Publicado no Oncotarget (2016)

Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe

Por Cogo, Francesco, Poreba, Marcin, Rut, Wioletta, Groborz, Katarzyna, Smyth, Peter, Johnston, Michael C., Williams, Richard, Longley, Daniel B., Burden, Roberta E., Salvesen, Guy S., Drag, Marcin, Scott, Christopher J.
Publicado no Nanoscale (2019)

Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer

Por Ferris, Jennifer, Espona-Fiedler, Margarita, Hamilton, Claudia, Holohan, Caitriona, Crawford, Nyree, McIntyre, Alex J., Roberts, Jamie Z., Wappett, Mark, McDade, Simon S., Longley, Daniel B., Coyle, Victoria
Publicado no Cell Death Discov (2020)