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Chemotherapy-induced activation of ADAM-17: a novel mechanism of drug resistance in colorectal cancer

PURPOSE: We have shown previously that exposure to anticancer drugs can trigger the activation of human epidermal receptor (HER) survival pathways in colorectal cancer (CRC). In this study, we examined the role of ADAMs (a desintegrin and metalloproteases) and soluble growth factors in this acute dr...

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Detalhes bibliográficos
Main Authors: Kyula, Joan N., Van Schaeybroeck, Sandra, Doherty, Joanne, Fenning, Catherine S., Longley, Daniel B., Johnston, Patrick G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896550/
https://ncbi.nlm.nih.gov/pubmed/20570921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0014
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