Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer

Pevonedistat (MLN4924), a selective inhibitor of the NEDD8-activating enzyme E1 regulatory subunit (NAE1), has demonstrated significant therapeutic potential in several malignancies. Although multiple mechanisms-of-action have been identified, how MLN4924 induces cell death and its potential as a co...

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Bibliografiske detaljer
Udgivet i:Cell Death Discov
Main Authors: Ferris, Jennifer, Espona-Fiedler, Margarita, Hamilton, Claudia, Holohan, Caitriona, Crawford, Nyree, McIntyre, Alex J., Roberts, Jamie Z., Wappett, Mark, McDade, Simon S., Longley, Daniel B., Coyle, Victoria
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7374701/
https://ncbi.nlm.nih.gov/pubmed/32714568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-00296-w
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