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The NAE inhibitor pevonedistat (MLN4924) synergizes with TNF-α to activate apoptosis
Predicting and understanding the mechanism of drug-induced toxicity is one of the primary goals of drug development. It has been hypothesized that inflammation may have a synergistic role in this process. Cell-based models provide an easily manipulated system to investigate this type of drug toxicit...
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| Publicado no: | Cell Death Discov |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4979425/ https://ncbi.nlm.nih.gov/pubmed/27551465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2015.34 |
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