The NAE inhibitor pevonedistat (MLN4924) synergizes with TNF-α to activate apoptosis

Predicting and understanding the mechanism of drug-induced toxicity is one of the primary goals of drug development. It has been hypothesized that inflammation may have a synergistic role in this process. Cell-based models provide an easily manipulated system to investigate this type of drug toxicit...

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Veröffentlicht in:Cell Death Discov
Hauptverfasser: Wolenski, F S, Fisher, C D, Sano, T, Wyllie, S D, Cicia, L A, Gallacher, M J, Baker, R A, Kirby, P J, Senn, J J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979425/
https://ncbi.nlm.nih.gov/pubmed/27551465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2015.34
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