KRAS mutant colorectal cancer gene signatures identified angiotensin II receptor blockers as potential therapies

Colorectal cancer (CRC) is a life-threatening disease with high prevalence and mortality worldwide. The KRAS oncogene is mutated in approximately 40% of CRCs. While antibody based EGFR inhibitors (cetuximab and panitumumab) represent a major treatment strategy for advanced KRAS wild type (KRAS-WT) C...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wen, Qing, Dunne, Philip D., O’Reilly, Paul G., Li, Gerald, Bjourson, Anthony J., McArt, Darragh G., Hamilton, Peter W., Zhang, Shu-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356876/
https://ncbi.nlm.nih.gov/pubmed/27965461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13884
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