Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapies

BACKGROUND: While the discovery of new drugs is a complex, lengthy and costly process, identifying new uses for existing drugs is a cost-effective approach to therapeutic discovery. Connectivity mapping integrates gene expression profiling with advanced algorithms to connect genes, diseases and smal...

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Detalhes bibliográficos
Publicado no:BMC Syst Biol
Main Authors: Wen, Qing, O'Reilly, Paul, Dunne, Philip D, Lawler, Mark, Van Schaeybroeck, Sandra, Salto-Tellez, Manuel, Hamilton, Peter, Zhang, Shu-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565135/
https://ncbi.nlm.nih.gov/pubmed/26356760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-9-S5-S4
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