HIV-1 vaccine immunogen design strategies

gan Mann, Jaclyn K, Ndung’u, Thumbi
Cyhoeddwyd yn Virol J (2015)

Genetic determinants of Nef-mediated CD4 and HLA class I down-regulation differences between HIV-1 subtypes B and C

gan Mann, Jaclyn K., Omarjee, Saleha, Khumalo, Phumzile, Ndung’u, Thumbi
Cyhoeddwyd yn Virol J (2015)

Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design

gan Ojwach, Doty B.A., Madlala, Paradise, Gordon, Michelle, Ndung’u, Thumbi, Mann, Jaclyn K.
Cyhoeddwyd yn Virology (2020)

Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design

gan Ferguson, Andrew L., Mann, Jaclyn K., Omarjee, Saleha, Ndung’u, Thumbi, Walker, Bruce D., Chakraborty, Arup K.
Cyhoeddwyd 2013

The Fitness Landscape of HIV-1 Gag: Advanced Modeling Approaches and Validation of Model Predictions by In Vitro Testing

gan Mann, Jaclyn K., Barton, John P., Ferguson, Andrew L., Omarjee, Saleha, Walker, Bruce D., Chakraborty, Arup, Ndung'u, Thumbi
Cyhoeddwyd 2014

Subtype-specific differences in Gag-protease replication capacity of HIV-1 isolates from East and West Africa

gan Farinre, Omotayo, Gounder, Kamini, Reddy, Tarylee, Tongo, Marcel, Hare, Jonathan, Chaplin, Beth, Gilmour, Jill, Kanki, Phyllis, Mann, Jaclyn K., Ndung’u, Thumbi
Cyhoeddwyd yn Retrovirology (2021)

Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection

gan Ojwach, Doty B. A., MacMillan, Daniel, Reddy, Tarylee, Novitsky, Vladimir, Brumme, Zabrina L., Brockman, Mark A., Ndung'u, Thumbi, Mann, Jaclyn K.
Cyhoeddwyd yn J Virol (2018)

Correction for Ojwach et al., “Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection”

gan Ojwach, Doty B. A., MacMillan, Daniel, Reddy, Tarylee, Novitsky, Vladimir, Brumme, Zabrina L., Brockman, Mark A., Ndung’u, Thumbi, Mann, Jaclyn K.
Cyhoeddwyd yn J Virol (2019)

Nef-mediated inhibition of NFAT following TCR stimulation differs between HIV-1 subtypes

gan Naidoo, Lisa, Mzobe, Zinhle, Jin, Steven W., Rajkoomar, Erasha, Reddy, Tarylee, Brockman, Mark A., Brumme, Zabrina L., Ndung’u, Thumbi, Mann, Jaclyn K.
Cyhoeddwyd yn Virology (2019)

Modelling and in vitro testing of the HIV-1 Nef fitness landscape

gan Barton, John P, Rajkoomar, Erasha, Mann, Jaclyn K, Murakowski, Dariusz K, Toyoda, Mako, Mahiti, Macdonald, Mwimanzi, Phillip, Ueno, Takamasa, Chakraborty, Arup K, Ndung’u, Thumbi
Cyhoeddwyd yn Virus Evol (2019)

High Frequency of Transmitted HIV-1 Gag HLA Class I-Driven Immune Escape Variants but Minimal Immune Selection over the First Year of Clade C Infection

gan Gounder, Kamini, Padayachi, Nagavelli, Mann, Jaclyn K., Radebe, Mopo, Mokgoro, Mammekwa, van der Stok, Mary, Mkhize, Lungile, Mncube, Zenele, Jaggernath, Manjeetha, Reddy, Tarylee, Walker, Bruce D., Ndung’u, Thumbi
Cyhoeddwyd yn PLoS One (2015)

Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiv...

gan Mwimanzi, Francis, Toyoda, Mako, Mahiti, Macdonald, Mann, Jaclyn K., Martin, Jeffrey N., Bangsberg, David, Brockman, Mark A., Goulder, Philip, Kirchhoff, Frank, Brumme, Zabrina L., Ndung'u, Thumbi, Ueno, Takamasa
Cyhoeddwyd yn J Virol (2017)

Subtype-Specific Differences in Gag-Protease-Driven Replication Capacity Are Consistent with Intersubtype Differences in HIV-1 Disease Progression

gan Kiguoya, Marion W., Mann, Jaclyn K., Chopera, Denis, Gounder, Kamini, Lee, Guinevere Q., Hunt, Peter W., Martin, Jeffrey N., Ball, T. Blake, Kimani, Joshua, Brumme, Zabrina L., Brockman, Mark A., Ndung'u, Thumbi
Cyhoeddwyd yn J Virol (2017)

Mother-to-Child HIV Transmission Bottleneck Selects for Consensus Virus with Lower Gag-Protease-Driven Replication Capacity

gan Naidoo, Vanessa L., Mann, Jaclyn K., Noble, Christie, Adland, Emily, Carlson, Jonathan M., Thomas, Jake, Brumme, Chanson J., Thobakgale-Tshabalala, Christina F., Brumme, Zabrina L., Brockman, Mark A., Goulder, Philip J. R., Ndung'u, Thumbi
Cyhoeddwyd yn J Virol (2017)

Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5

gan Jin, Steven W., Mwimanzi, Francis M., Mann, Jaclyn K., Bwana, Mwebesa Bosco, Lee, Guinevere Q., Brumme, Chanson J., Hunt, Peter W., Martin, Jeff N., Bangsberg, David R., Ndung’u, Thumbi, Brumme, Zabrina L., Brockman, Mark A.
Cyhoeddwyd yn PLoS Pathog (2020)

No Evidence for Selection of HIV-1 with Enhanced Gag-Protease or Nef Function among Breakthrough Infections in the CAPRISA 004 Tenofovir Microbicide Trial

gan Chopera, Denis R., Mann, Jaclyn K., Mwimanzi, Philip, Omarjee, Saleha, Kuang, Xiaomei T., Ndabambi, Nonkululeko, Goodier, Sarah, Martin, Eric, Naranbhai, Vivek, Karim, Salim Abdool, Karim, Quarraisha Abdool, Brumme, Zabrina L., Ndung'u, Thumbi, Williamson, Carolyn, Brockman, Mark A.
Cyhoeddwyd 2013

Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection

gan Muema, Daniel M., Akilimali, Ngomu A., Ndumnego, Okechukwu C., Rasehlo, Sipho S., Durgiah, Raveshni, Ojwach, Doty B.A., Ismail, Nasreen, Dong, Mary, Moodley, Amber, Dong, Krista L., Ndhlovu, Zaza M., Mabuka, Jenniffer M., Walker, Bruce D., Mann, Jaclyn K., Ndung’u, Thumbi
Cyhoeddwyd yn BMC Med (2020)

Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure

gan Mann, Jaclyn K., Chopera, Denis, Omarjee, Saleha, Kuang, Xiaomei T., Le, Anh Q., Anmole, Gursev, Danroth, Ryan, Mwimanzi, Philip, Reddy, Tarylee, Carlson, Jonathan, Radebe, Mopo, Goulder, Philip J.R., Walker, Bruce D., Karim, Salim Abdool, Novitsky, Vladimir, Williamson, Carolyn, Brockman, Mark A., Brumme, Zabrina L., Ndung’u, Thumbi
Cyhoeddwyd yn Virology (2014)

Intersubtype Differences in the Effect of a Rare p24 Gag Mutation on HIV-1 Replicative Fitness

gan Chopera, Denis R., Cotton, Laura A., Zawaira, Alexander, Mann, Jaclyn K., Ngandu, Nobubelo K., Ntale, Roman, Carlson, Jonathan M., Mlisana, Koleka, Woodman, Zenda, de Assis Rosa, Debra, Martin, Eric, Miura, Toshiyuki, Pereyra, Florencia, Walker, Bruce D., Gray, Clive M., Martin, Darren P., Ndung'u, Thumbi, Brockman, Mark A., Karim, Salim Abdool, Brumme, Zabrina L., Williamson, Carolyn
Cyhoeddwyd 2012

Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

gan Mann, Jaclyn K, Byakwaga, Helen, Kuang, Xiaomei T, Le, Anh Q, Brumme, Chanson J, Mwimanzi, Philip, Omarjee, Saleha, Martin, Eric, Lee, Guinevere Q, Baraki, Bemuluyigza, Danroth, Ryan, McCloskey, Rosemary, Muzoora, Conrad, Bangsberg, David R, Hunt, Peter W, Goulder, Philip JR, Walker, Bruce D, Harrigan, P Richard, Martin, Jeff N, Ndung’u, Thumbi, Brockman, Mark A, Brumme, Zabrina L
Cyhoeddwyd 2013