Subtype-Specific Differences in Gag-Protease-Driven Replication Capacity Are Consistent with Intersubtype Differences in HIV-1 Disease Progression

There are marked differences in the spread and prevalence of HIV-1 subtypes worldwide, and differences in clinical progression have been reported. However, the biological reasons underlying these differences are unknown. Gag-protease is essential for HIV-1 replication, and Gag-protease-driven replic...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Kiguoya, Marion W., Mann, Jaclyn K., Chopera, Denis, Gounder, Kamini, Lee, Guinevere Q., Hunt, Peter W., Martin, Jeffrey N., Ball, T. Blake, Kimani, Joshua, Brumme, Zabrina L., Brockman, Mark A., Ndung'u, Thumbi
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469260/
https://ncbi.nlm.nih.gov/pubmed/28424286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00253-17
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