Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals

Patient-derived HIV-1 subtype B Nef clones downregulate HLA-A more efficiently than HLA-B. However, it remains unknown whether this property is common to Nef proteins across primate lentiviruses and how antiviral immune responses may be affected. We examined 263 Nef clones from diverse primate lenti...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Mwimanzi, Francis, Toyoda, Mako, Mahiti, Macdonald, Mann, Jaclyn K., Martin, Jeffrey N., Bangsberg, David, Brockman, Mark A., Goulder, Philip, Kirchhoff, Frank, Brumme, Zabrina L., Ndung'u, Thumbi, Ueno, Takamasa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730772/
https://ncbi.nlm.nih.gov/pubmed/29046444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01409-17
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