Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5

HIV Nef counteracts cellular host restriction factors SERINC3 and SERINC5, but our understanding of how naturally occurring global Nef sequence diversity impacts these activities is limited. Here, we quantify SERINC3 and SERINC5 internalization function for 339 Nef clones, representing the major pan...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Jin, Steven W., Mwimanzi, Francis M., Mann, Jaclyn K., Bwana, Mwebesa Bosco, Lee, Guinevere Q., Brumme, Chanson J., Hunt, Peter W., Martin, Jeff N., Bangsberg, David R., Ndung’u, Thumbi, Brumme, Zabrina L., Brockman, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515180/
https://ncbi.nlm.nih.gov/pubmed/32925973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008813
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