Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5

HIV Nef counteracts cellular host restriction factors SERINC3 and SERINC5, but our understanding of how naturally occurring global Nef sequence diversity impacts these activities is limited. Here, we quantify SERINC3 and SERINC5 internalization function for 339 Nef clones, representing the major pan...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Pathog
Prif Awduron: Jin, Steven W., Mwimanzi, Francis M., Mann, Jaclyn K., Bwana, Mwebesa Bosco, Lee, Guinevere Q., Brumme, Chanson J., Hunt, Peter W., Martin, Jeff N., Bangsberg, David R., Ndung’u, Thumbi, Brumme, Zabrina L., Brockman, Mark A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515180/
https://ncbi.nlm.nih.gov/pubmed/32925973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008813
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