Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes

Downregulation of BST-2/tetherin and CD4 by HIV-1 viral protein U (Vpu) promotes viral egress and allows infected cells to evade host immunity. Little is known however about the natural variability in these Vpu functions among the genetically diverse viral subtypes that contribute to the HIV-1 pande...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Umviligihozo, Gisele, Cobarrubias, Kyle D., Chandrarathna, Sandali, Jin, Steven W., Reddy, Nicole, Byakwaga, Helen, Muzoora, Conrad, Bwana, Mwebesa B., Lee, Guinevere Q., Hunt, Peter W., Martin, Jeff N., Brumme, Chanson J., Bangsberg, David R., Karita, Etienne, Allen, Susan, Hunter, Eric, Ndung’u, Thumbi, Brumme, Zabrina L., Brockman, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343213/
https://ncbi.nlm.nih.gov/pubmed/32376625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00293-20
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares