Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes

Downregulation of BST-2/tetherin and CD4 by HIV-1 viral protein U (Vpu) promotes viral egress and allows infected cells to evade host immunity. Little is known however about the natural variability in these Vpu functions among the genetically diverse viral subtypes that contribute to the HIV-1 pande...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Virol
Egile Nagusiak: Umviligihozo, Gisele, Cobarrubias, Kyle D., Chandrarathna, Sandali, Jin, Steven W., Reddy, Nicole, Byakwaga, Helen, Muzoora, Conrad, Bwana, Mwebesa B., Lee, Guinevere Q., Hunt, Peter W., Martin, Jeff N., Brumme, Chanson J., Bangsberg, David R., Karita, Etienne, Allen, Susan, Hunter, Eric, Ndung’u, Thumbi, Brumme, Zabrina L., Brockman, Mark A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2020
Gaiak:
Pathogenesis and Immunity
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343213/
https://ncbi.nlm.nih.gov/pubmed/32376625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00293-20
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