Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8(+) T cells. Polymorphic residues within the HLA cytoplasmic region may affect Nef’s downregulation activity. However, the effe...

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Bibliographic Details
Published in:mBio
Main Authors: Mahiti, Macdonald, Toyoda, Mako, Jia, Xiaofei, Kuang, Xiaomei T., Mwimanzi, Francis, Mwimanzi, Philip, Walker, Bruce D., Xiong, Yong, Brumme, Zabrina L., Brockman, Mark A., Ueno, Takamasa
Format: Artigo
Language:Inglês
Published: American Society of Microbiology 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724998/
https://ncbi.nlm.nih.gov/pubmed/26787826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01516-15
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