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Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences
HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8(+) T cells. Polymorphic residues within the HLA cytoplasmic region may affect Nef’s downregulation activity. However, the effe...
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| Published in: | mBio |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society of Microbiology
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4724998/ https://ncbi.nlm.nih.gov/pubmed/26787826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01516-15 |
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