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Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design
A prophylactic or therapeutic vaccine offers the best hope to curb the HIV-AIDS epidemic gripping sub-Saharan Africa, but remains elusive. A major challenge is the extreme viral sequence variability among strains. Systematic means to guide immunogen design for highly variable pathogens like HIV are...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3728823/ https://ncbi.nlm.nih.gov/pubmed/23521886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.11.022 |
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