Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design

A prophylactic or therapeutic vaccine offers the best hope to curb the HIV-AIDS epidemic gripping sub-Saharan Africa, but remains elusive. A major challenge is the extreme viral sequence variability among strains. Systematic means to guide immunogen design for highly variable pathogens like HIV are...

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Bibliographic Details
Main Authors: Ferguson, Andrew L., Mann, Jaclyn K., Omarjee, Saleha, Ndung’u, Thumbi, Walker, Bruce D., Chakraborty, Arup K.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728823/
https://ncbi.nlm.nih.gov/pubmed/23521886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.11.022
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