Intersubtype Differences in the Effect of a Rare p24 Gag Mutation on HIV-1 Replicative Fitness

Certain immune-driven mutations in HIV-1, such as those arising in p24(Gag), decrease viral replicative capacity. However, the intersubtype differences in the replicative consequences of such mutations have not been explored. In HIV-1 subtype B, the p24(Gag) M250I mutation is a rare variant (0.6%) t...

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Αποθηκεύτηκε σε:
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Κύριοι συγγραφείς: Chopera, Denis R., Cotton, Laura A., Zawaira, Alexander, Mann, Jaclyn K., Ngandu, Nobubelo K., Ntale, Roman, Carlson, Jonathan M., Mlisana, Koleka, Woodman, Zenda, de Assis Rosa, Debra, Martin, Eric, Miura, Toshiyuki, Pereyra, Florencia, Walker, Bruce D., Gray, Clive M., Martin, Darren P., Ndung'u, Thumbi, Brockman, Mark A., Karim, Salim Abdool, Brumme, Zabrina L., Williamson, Carolyn
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2012
Θέματα:
Pathogenesis and Immunity
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503133/
https://ncbi.nlm.nih.gov/pubmed/23015721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02171-12
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