Intersubtype Differences in the Effect of a Rare p24 Gag Mutation on HIV-1 Replicative Fitness

Certain immune-driven mutations in HIV-1, such as those arising in p24(Gag), decrease viral replicative capacity. However, the intersubtype differences in the replicative consequences of such mutations have not been explored. In HIV-1 subtype B, the p24(Gag) M250I mutation is a rare variant (0.6%) t...

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Detalhes bibliográficos
Main Authors: Chopera, Denis R., Cotton, Laura A., Zawaira, Alexander, Mann, Jaclyn K., Ngandu, Nobubelo K., Ntale, Roman, Carlson, Jonathan M., Mlisana, Koleka, Woodman, Zenda, de Assis Rosa, Debra, Martin, Eric, Miura, Toshiyuki, Pereyra, Florencia, Walker, Bruce D., Gray, Clive M., Martin, Darren P., Ndung'u, Thumbi, Brockman, Mark A., Karim, Salim Abdool, Brumme, Zabrina L., Williamson, Carolyn
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503133/
https://ncbi.nlm.nih.gov/pubmed/23015721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02171-12
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