Intersubtype Differences in the Effect of a Rare p24 Gag Mutation on HIV-1 Replicative Fitness

Certain immune-driven mutations in HIV-1, such as those arising in p24(Gag), decrease viral replicative capacity. However, the intersubtype differences in the replicative consequences of such mutations have not been explored. In HIV-1 subtype B, the p24(Gag) M250I mutation is a rare variant (0.6%) t...

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Main Authors: Chopera, Denis R., Cotton, Laura A., Zawaira, Alexander, Mann, Jaclyn K., Ngandu, Nobubelo K., Ntale, Roman, Carlson, Jonathan M., Mlisana, Koleka, Woodman, Zenda, de Assis Rosa, Debra, Martin, Eric, Miura, Toshiyuki, Pereyra, Florencia, Walker, Bruce D., Gray, Clive M., Martin, Darren P., Ndung'u, Thumbi, Brockman, Mark A., Karim, Salim Abdool, Brumme, Zabrina L., Williamson, Carolyn
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503133/
https://ncbi.nlm.nih.gov/pubmed/23015721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02171-12
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