Impact of HLA-B*81-Associated Mutations in HIV-1 Gag on Viral Replication Capacity

HIV-1 attenuation resulting from immune escape mutations selected in Gag may contribute to slower disease progression in HIV-1-infected individuals expressing certain HLA class I alleles. We previously showed that the protective allele HLA-B*81 and the HLA-B*81-selected Gag T186S mutation are strong...

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Detalhes bibliográficos
Main Authors: Wright, Jaclyn K., Naidoo, Vanessa L., Brumme, Zabrina L., Prince, Jessica L., Claiborne, Daniel T., Goulder, Philip J. R., Brockman, Mark A., Hunter, Eric, Ndung'u, Thumbi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302318/
https://ncbi.nlm.nih.gov/pubmed/22238317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06682-11
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