Gag-Protease-Mediated Replication Capacity in HIV-1 Subtype C Chronic Infection: Associations with HLA Type and Clinical Parameters

The mechanisms underlying HIV-1 control by protective HLA class I alleles are not fully understood and could involve selection of escape mutations in functionally important Gag epitopes resulting in fitness costs. This study was undertaken to investigate, at the population level, the impact of HLA-m...

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Detalhes bibliográficos
Main Authors: Wright, Jaclyn K., Brumme, Zabrina L., Carlson, Jonathan M., Heckerman, David, Kadie, Carl M., Brumme, Chanson J., Wang, Bingxia, Losina, Elena, Miura, Toshiyuki, Chonco, Fundisiwe, van der Stok, Mary, Mncube, Zenele, Bishop, Karen, Goulder, Philip J. R., Walker, Bruce D., Brockman, Mark A., Ndung'u, Thumbi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950592/
https://ncbi.nlm.nih.gov/pubmed/20702636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01084-10
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