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APOBEC3G Expression is Dysregulated in Primary HIV-1 Infection and a Polymorphic Variant Influences CD4+ T Cell Counts and Plasma Viral Load
OBJECTIVES: In the absence of HIV-1 Vif, cellular cytosine deaminases such as APOBEC3G, inhibit the virus by inducing hypermutations on viral DNA, among other mechanisms of action. We investigated the association of APOBEC3G mRNA levels and APOBEC3G genetic variants on HIV-1 susceptibility, and earl...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3470914/ https://ncbi.nlm.nih.gov/pubmed/19996938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3283353bba |
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