Association of Polymorphisms in the LEDGF/p75 Gene (PSIP1) with Susceptibility to HIV-1 Infection and Disease Progression

OBJECTIVE: LEDGF/p75, encoded by the PSIP1 gene, interacts with HIV-1 integrase and targets HIV-1 integration into active genes. We investigated the influence of polymorphisms in PSIP1 on HIV-1 acquisition and disease progression in black South Africans. METHODS: Integrase binding domain (IBD) of LE...

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Autors principals: Madlala, Paradise, Gijsbers, Rik, Christ, Frauke, Hombrouck, Anneleen, Werner, Lise, Mlisana, Koleka, An, Ping, Karim, Salim S. Abdool, Winkler, Cheryl A., Debyser, Zeger, Ndung'u, Thumbi
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233670/
https://ncbi.nlm.nih.gov/pubmed/21681054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e328349c693
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