Virus Evolution Reveals an Exclusive Role for LEDGF/p75 in Chromosomal Tethering of HIV

Retroviruses by definition insert their viral genome into the host cell chromosome. Although the key player of retroviral integration is viral integrase, a role for cellular cofactors has been proposed. Lentiviral integrases use the cellular protein LEDGF/p75 to tether the preintegration complex to...

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Hauptverfasser: Hombrouck, Anneleen, De Rijck, Jan, Hendrix, Jelle, Vandekerckhove, Linos, Voet, Arnout, Maeyer, Marc De, Witvrouw, Myriam, Engelborghs, Yves, Christ, Frauke, Gijsbers, Rik, Debyser, Zeger
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2007
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1839165/
https://ncbi.nlm.nih.gov/pubmed/17397262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0030047
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