Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus Replication

We initially identified lens epithelium-derived growth factor/p75 (LEDGF/p75) as a binding partner of human immunodeficiency virus type 1 (HIV-1) integrase. To investigate the role of LEDGF/p75 in HIV replication and its potential as a new antiviral target, we stably overexpressed two different frag...

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Detalhes bibliográficos
Main Authors: De Rijck, Jan, Vandekerckhove, Linos, Gijsbers, Rik, Hombrouck, Anneleen, Hendrix, Jelle, Vercammen, Jo, Engelborghs, Yves, Christ, Frauke, Debyser, Zeger
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1642583/
https://ncbi.nlm.nih.gov/pubmed/16987986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00801-06
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