Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency Virus

After identifying the interaction between the transcriptional coactivator lens epithelium-derived growth factor (LEDGF/p75) and the human immunodeficiency virus type 1 (HIV-1) integrase (IN), we have now investigated the role of LEDGF/p75 during HIV replication. Transient small interfering RNA-media...

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Detalhes bibliográficos
Main Authors: Vandekerckhove, Linos, Christ, Frauke, Van Maele, Bénédicte, De Rijck, Jan, Gijsbers, Rik, Van den Haute, Chris, Witvrouw, Myriam, Debyser, Zeger
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367129/
https://ncbi.nlm.nih.gov/pubmed/16439544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.4.1886-1896.2006
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