Intersubtype Differences in the Effect of a Rare p24 Gag Mutation on HIV-1 Replicative Fitness

Certain immune-driven mutations in HIV-1, such as those arising in p24(Gag), decrease viral replicative capacity. However, the intersubtype differences in the replicative consequences of such mutations have not been explored. In HIV-1 subtype B, the p24(Gag) M250I mutation is a rare variant (0.6%) t...

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Bibliographic Details
Main Authors: Chopera, Denis R., Cotton, Laura A., Zawaira, Alexander, Mann, Jaclyn K., Ngandu, Nobubelo K., Ntale, Roman, Carlson, Jonathan M., Mlisana, Koleka, Woodman, Zenda, de Assis Rosa, Debra, Martin, Eric, Miura, Toshiyuki, Pereyra, Florencia, Walker, Bruce D., Gray, Clive M., Martin, Darren P., Ndung'u, Thumbi, Brockman, Mark A., Karim, Salim Abdool, Brumme, Zabrina L., Williamson, Carolyn
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503133/
https://ncbi.nlm.nih.gov/pubmed/23015721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02171-12
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